About EPI in Pancreatic Cancer

What You Should Know: Exocrine Pancreatic Insufficiency (EPI) in Pancreatic Cancer

Pancreatic Cancer Overview

Pancreatic cancer is the
3rd leading
Cause of cancer-related
death in the United States¹

Majority of pancreatic tumors are exocrine, most of which are adenocarcinomas²

Estimated incidence in the US: 62,200 cases³

Represents 3.2% of all new cancer cases³

Incidence: 13.3 and 11.1 per 100,000 males and females, respectively³

Etiologies of EPI in Pancreatic Cancer

Obstruction of pancreatic duct by tumors⁵

Pancreatic atrophy or fibrosis secondary to tumor(s)⁶

Complications of pancreatic resection^6,7

Reduction of glandular tissue
Fibrosis in the remaining pancreatic remnant
Alteration of pancreatic anatomy
Extensive denervation following lymph node dissection

Incidence of EPI in Pancreatic Cancer

50-90% of patients with unresectable pancreatic cancer develop EPI⁸

In patients with resectable pancreatic cancer,
EPI occurs in 46-68% of patients prior to surgery,^9-11
increasing to 55-89%of patients after surgery^9,10,12,13

References:

1. American Cancer Society. Cancer Facts & Figures 2022. https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2022.html. Accessed January 23, 2023. 2. Pancreatic Cancer Action Network. Types of pancreatic cancer. https://pancan.org/facing-pancreatic-cancer/about-pancreatic-cancer/types-of-pancreatic-cancer/. Published September 29, 2021. Accessed January 23, 2023. 3. SEER Cancer Stat Facts: Pancreatic Cancer. National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/statfacts/html/pancreas.html. Accessed January 23, 2023. 4. Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Cancer Res. 2014;74(11):2913-21. 5. Vujasinovic M et al. Nutrients. 2017;9(3).pii:E183. 6. Ghaneh P, Neoptolemos J P. Ann N Y Acad Sci. 1999;880:308-318. 7. Bartel MJ, Asbun H, Stauffer J, Raimondo M. Dig Liver Dis. 2015;47(12):1013-1020. 8. Perbtani Y, Forsmark CE. F1000Res. 2019;8:F1000 Faculty Rev-1991. 9. Sikkens EC et al. Br J Sure. 2014;101(2):109-113. 10. Belyaev O, Herzog T, Chromik AM, Meurer K, Uhl W. Langenbecks Arch Surgery. 2013;398(4):547-555. 11. Matsumoto J, Traverso LW. J Gastrointest Surg. 2006;10(9);1225-1229. 12. Halloran CM et al. Pancreatology. 2011;11(6):535-545. 13. Roeyen G, Jansen M, Ruyssinck L, et al. HPB (Oxford). 2016;18(12):1017-1022.