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EPI in Primary Care

Practical Diagnosis and Management of EPI


Exocrine pancreatic insufficiency (EPI) is a condition that occurs due to a reduction in pancreatic enzyme production, delivery, and/or activity to a level below the threshold required to maintain normal digestion. EPI results in impaired digestion and decreased absorption of nutrients.1,2


EPI should always be considered in individuals with a newly diagnosed pancreatic disease predisposing to EPI, including chronic pancreatitis, cystic fibrosis, pancreatic cancer, pancreatectomy, and gastrointestinal surgeries.3*


Investigate EPI if suggestive signs and symptoms develop in a patient with a known pancreatic disease or in patients with a predisposing condition.

The following signs and symptoms should be considered suggestive of EPI:


For patients with a condition predisposing to EPI, regular screening should include:


For patients with signs or symptoms suggestive of EPI, thorough investigation should include the following considerations:

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